Receptor-independent cellular uptake of pituitary adenylate cyclase-activating polypeptide
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چکیده
منابع مشابه
Pituitary adenylate cyclase activating polypeptide and migraine
Pituitary adenylate cyclase activating peptide (PACAP) is found in human trigeminocervical complex and can trigger migraine. PACAP levels were measured using a sensitive radioimmunoassay. Stimulation of the superior sagittal sinus (SSS) in cat elevated PACAP levels in cranial blood. Patients with moderate or severe migraine headache had elevated PACAP in the external jugular vein during headach...
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PITUITARY ADENYLATE CYCLASE-activating polypeptide (PACAP) is an ancestral molecule for a superfamily of 11 hormones and hormone-like substances that have a secretin-containing core in common. These include PACAP, glucagon, glucagon-like peptide-1 and -2, growth hormone-releasing hormone, VIP, peptide histidine methionine, secretin, and glucose-dependent insulinotropic polypeptide (see extensiv...
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Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 38-amino acid peptide (PACAP38) or a truncated peptide with the same 27 amino-terminal residues (PACAP27). The PACAP receptor was solubilized from bovine brain membranes with digitonin and purified 30-fold by the combination of DEAE-Toyopearl and hydroxylapatite chromatographic analyses. The partially purified PACAP receptors were ...
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Pituitary adenylate cyclase-activating peptide I receptor (PAC1R) is member of the B class of G protein-coupled seven-transmembrane receptors, with molecular functions associated with neural cell differentiation, regeneration and the inhibition of apoptosis. However, the integrity of the protein structure is difficult to be determined in vitro. In the present study, the physicochemical properti...
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It is well known that the pituitary gonadotropin surge induces progesterone receptor (PR) gene expression in luteinizing granulosa cells and that PR activation is critical for successful ovulation. To further understand the molecular mechanism(s) by which PR plays a role critical for granulosa cell functions, we wanted to identify progesterone-induced genes in granulosa cells. We employed a PCR...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
سال: 2012
ISSN: 0167-4889
DOI: 10.1016/j.bbamcr.2012.02.001